Triple threat treatment: Exploiting the dependence receptor properties of metabotropic glutamate receptor 1 against melanoma
نویسندگان
چکیده
Melanoma cells that express metabotropic glutamate 1 (mGlu1) receptors depend on glutamate for their survival and proliferation. The dependence receptor properties of mGlu1 allow us to propose and justify three promising approaches for melanoma treatment: glutamate depletion, mGlu1 receptor antagonism, and targeting of mGlu1 receptor signaling.
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عنوان ژورنال:
دوره 1 شماره
صفحات -
تاریخ انتشار 2014